• Cochrane Db Syst Rev · Jun 2024

    Review

    Ultrasound and blind endometrial sampling for detection of endometrial cancer in women with postmenopausal bleeding.

    • Selvi Radhika Vikram, Jonathan Robinson, Tina Thanawala, John Franklin, Shari Boeckstaens, Marcia Hall, Fatai Adegboyega Sanusi, Malcolm Padwick, and Paul Stanciu.
    • Women and Children's Services, West Hertfordshire Hospitals NHS Trust, St Albans, UK.
    • Cochrane Db Syst Rev. 2024 Jun 20; 6 (6): CD014568CD014568.

    AbstractThis is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To assess the diagnostic accuracy of endometrial sampling with histology in the diagnosis of endometrial cancer in women with postmenopausal bleeding and thickened endometrium on ultrasound. Diagnosis will be verified by the reference standards, hysteroscopy with histology, obtained by targeted (such as grasp biopsy of the endometrium or resection of focal pathology) or global sampling (with dilation and curettage), and histology of hysterectomy specimens. Secondary objectives To determine the diagnostic accuracy of different sampling devices and methods in the detection of endometrial cancer To assess the diagnostic accuracy of endometrial sampling devices and methods to detect endometrial hyperplasia To determine accuracy in diagnosing endometrial cancer and endometrial hyperplasia at different endometrial thicknesses of 3 mm, 4 mm and 5 mm To investigate sources of heterogeneity.Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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