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  • Medicine · Nov 2024

    Review

    Transcription factors in tanshinones: Emerging mechanisms of transcriptional regulation.

    • Yanyun Pan, Jin Dai, Minwei Jin, Qiujun Zhou, Xiaoliang Jin, and Jinjie Zhang.
    • Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
    • Medicine (Baltimore). 2024 Nov 22; 103 (47): e40343e40343.

    AbstractTranscription factors play a crucial role in the biosynthesis of tanshinones, which are significant secondary metabolites derived from Salvia miltiorrhiza, commonly known as Danshen. These compounds have extensive pharmacological properties, including anti-inflammatory and cardioprotective effects. This review delves into the roles of various transcription factor families, such as APETALA2/ethylene response factor, basic helix-loop-helix, myeloblastosis, basic leucine zipper, and WRKY domain-binding protein, in regulating the biosynthetic pathways of tanshinones. We discuss the emerging mechanisms by which these transcription factors influence the synthesis of tanshinones, both positively and negatively, by directly regulating gene expression or forming complex regulatory networks. Additionally, the review highlights the potential applications of these insights in enhancing tanshinone production through genetic and metabolic engineering, setting the stage for future advancements in medicinal plant research.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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