• Nutrition · Jan 2025

    Fiber, lactose and fat-modified diet for the prevention of gastrointestinal chemo-radiotherapy-induced toxicity in patients with cervical cancer: Randomized clinical trial.

    • Laura Flores-Cisneros, Lucely Cetina-Pérez, Julissa Luvián-Morales, Tatiana Galicia-Carmona, Roberto Jiménez-Morales, Miriam Sánchez-López, and Lilia Castillo-Martínez.
    • Division of Clinical Research, Instituto Nacional de Cancerología de México, 14080 Mexico City, Mexico; Postgraduate Programs, Universidad Nacional Autónoma de México, 14510 Mexico City, Mexico.
    • Nutrition. 2025 Jan 2; 132: 112682112682.

    BackgroundThe most frequent early gastrointestinal (GI) toxicity symptoms are nausea (58%), diarrhea (46.7%), and vomiting (45.5%) in patients with cervical cancer (CC). Approximately 90% of patients undergoing abdominopelvic radiotherapy present with changes in the GI tract, such as degenerative alterations in mucosal epithelial cells and nutrient malabsorption.ObjectiveTo evaluate the effect of a diet modified in fiber, lactose, and fat on the prevention of chemoradiotherapy (QTRT)-induced GI toxicity compared to the usual prescription in women with locally advanced CC.MethodsA total of 134 women with a confirmed diagnosis of CC in locally advanced stages (IB2-IVA) were included in a randomized clinical trial conducted between February 2017 and March 2020. The intervention group (IG) received a modified diet of fiber, lactose, and fat, while the usual prescription group (UP) followed habitual nutritional recommendations. Toxicity was measured using the Common Terminology Criteria for Adverse Events (CTCAE) v4.ResultsA total of 134 women were included in the IG (65) and UP (69) groups. The mean age in the IG and UP groups were 47.2±13.4 and 49.7±14.2 years, respectively. Radiotherapy doses received by the IG and UP groups were 50.1±6.7 and 49.9±4.6 Gy, respectively. IG had a lower risk of presenting with mild constipation compared to the UP (hazard ratio: 0.46, 95% confidence interval: 0.28-0.76, P<0.01).ConclusionPatients with locally advanced stages of CC undergoing QTRT who received fiber, lactose, and fat-modified diet may have a lower risk of mild constipation during abdominal radiotherapy.Copyright © 2024 Elsevier Inc. All rights reserved.

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