• World Neurosurg · Jan 2025

    Impact of Spinal Instrumentation on Early Postoperative Inflammatory Markers: A Comparative Analysis in the Same Patient Cohort with or without Instrumentation.

    • Hiroyuki Aono, Shota Takenaka, Yukitaka Nagamoto, Hidekazu Tobimatsu, Tomoya Yamashita, Masayuki Furuya, Hiroyuki Ishiguro, and Motoki Iwasaki.
    • Department of Orthopedic Surgery, Osaka Global Orthopedic Hospital, 6-15-30 Sekime, Joto-ku, Osaka city, Osaka 5360008, Japan. Electronic address: h-aono@umin.ac.jp.
    • World Neurosurg. 2025 Jan 22: 123681123681.

    BackgroundsPostoperative inflammatory parameters are important markers of surgical site infection. Some authors have reported that spine surgery with instrumentation elevates CRP levels more than that without instrumentation does. However, those studies compared early postoperative inflammatory markers with or without instrumentation in different patients, although CRP levels vary widely among patients. Therefore, we investigated the impact of early postoperative inflammatory reaction with or without instrumentation in the same patients.MethodsData were examined for 72 patients who had undergone lumbar surgery twice, once with instrumentation and once without instrumentation. CRP level, white blood cell (WBC) count, and neutrophil count (NC) were measured before surgery and at 1, 3, 7, and 14 days after surgery. All surgery with instrumentation were PLIF and all without instrumentation were laminotomy.ResultsComparison of peak CRP between procedures with instrumentation and those without instrumentation showed a consistent peak on day 3 for all patients across both types of surgical procedures. After PLIF, there was a significantly elevated CRP, WBC, and NC in comparison to these for laminotomy. There were significant interactions between time and PLIF in relation to CRP, WBC, and NC levels. There were significant interactions between time and number of levels (N-level) in relation to CRP and NC. Age, gender, blood loss, and duration of surgery did not influence the observed elevations of all markers.ConclusionsEarly postoperative trends were significantly higher after PLIF than after laminotomy for all three indices, with a significant interaction between time and N-level for CRP and NC.Copyright © 2025. Published by Elsevier Inc.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…