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Acta Anaesthesiol Scand · Jul 1985
Comparative StudyEdrophonium and neostigmine for reversal of the neuromuscular blocking effect of vecuronium.
- J Engbaek, H Ording, D Ostergaard, and J Viby-Mogensen.
- Acta Anaesthesiol Scand. 1985 Jul 1;29(5):544-6.
AbstractThe effect of edrophonium for reversal of the non-depolarizing neuromuscular blockade produced by a continuous infusion of vecuronium was compared to that of neostigmine in 20 adult patients during neurolept anaesthesia. When antagonism was attempted at 10% twitch height recovery, reversal time to a train-of-four ratio of 0.7 was significantly shorter following neostigmine 0.04 mg/kg than after edrophonium 0.75 mg/kg (9.8 min and 18.7 min, respectively) but the same after edrophonium 1.5 mg/kg (10.3 min). There was no statistically significant difference in reversal time between neostigmine 0.04 mg/kg given at 10% twitch height and edrophonium 0.75 mg/kg given at 25% twitch height recovery (6.0 min). Additional doses of atropine were necessary following edrophonium 1.5 mg/kg.
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