• Anaesthesia · Oct 2007

    Randomized Controlled Trial

    Epidural infusion of levobupivacaine and sufentanil following thoracotomy.

    • G De Cosmo, E Congedo, A Mascia, E Adducci, C Lai, and P Aceto.
    • Department of Anaesthesiology and Intensive Care, Policlinico Universitario A. Gemelli, Rome, Italy. gdecosmo@rm.unicatt.it
    • Anaesthesia. 2007 Oct 1;62(10):994-9.

    AbstractA prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. A total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. An epidural catheter was inserted between the levels of T4 and T6 before induction of anaesthesia and a loading dose of levobupivacaine and sufentanil was administered. At the end of surgery an epidural infusion was commenced at 5 mlxh(-1) and continued for 48 h. Patients were randomly allocated to receive either levobupivacaine 0.125% (group A) or 0.0625% (group B) and all patients also received sufentanil (1 microgxml(-1)). Visual analogue pain scores after coughing (VASi) were always higher in group B (p < 0.05); VAS pain scores at rest were higher for the first 4 h and at 16 and 28 h in group B (p < 0.05). Total morphine consumption and requests number was lower in group A (p < 0.05). Better pain relief was achieved using epidural 0.125% levobupivacaine.

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