• Can J Anaesth · Dec 2003

    Randomized Controlled Trial Clinical Trial

    Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control.

    • Jann-Inn Tzeng, Koung-Shing Chu, Shung-Tai Ho, Kuang-I Cheng, Kuo-Sheng Liu, and Jhi-Joung Wang.
    • Departments of Medical Research and Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.
    • Can J Anaesth. 2003 Dec 1;50(10):1023-6.

    PurposeTo evaluate the prophylactic effect of ondansetron on nausea and vomiting following epidural morphine for postoperative pain control.MethodsSeventy women (n = 35 in each group) undergoing abdominal total hysterectomy under epidural anesthesia were enrolled in this randomized, double-blinded, and placebo-controlled study. At the end of surgery, all patients received epidural morphine 3 mg for postoperative pain relief. Before morphine injection, the ondansetron group received iv ondansetron 4 mg, whereas the placebo group received iv saline.ResultsPatients in the ondansetron group reported a lower frequency of total postoperative nausea and vomiting (22%) and lower frequency of rescue antiemetic request (12%) than those in the placebo group (52% and 39%, respectively; P < 0.05). In addition, ondansetron was associated with a reduced incidence of pruritus following epidural morphine (28% vs 58%; P < 0.05).ConclusionWe conclude that iv ondansetron 4 mg is effective in the prevention of nausea, vomiting, and pruritus following epidural morphine for postoperative pain control.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…