• Anaesthesia · Apr 1996

    Randomized Controlled Trial Comparative Study Clinical Trial

    Modification of pain on injection of propofol. A comparison of pethidine and lignocaine.

    • B Lyons, D Lohan, C Flynn, and M McCarroll.
    • Department of Anaesthesia, Cappagh Orthopaedic Hospital, Dublin, Ireland.
    • Anaesthesia. 1996 Apr 1;51(4):394-5.

    AbstractOne hundred and fifty ASA 1 and 2 patients were randomly allocated to receive pethidine 25 mg (1 ml), lignocaine 10 mg (1 ml) or 0.9% saline (1 ml) on a double-blind basis, as pretreatment to reduce pain on injection of propofol. Both active treatments were significantly better than placebo at preventing pain (p < 0.01). Lignocaine was most effective in preventing pain in men (p < 0.05) whilst pethidine was more effective in women (p < 0.05).

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