• Dement Geriatr Cogn Disord · Jan 2010

    Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities.

    • Vincent C T Mok, Adrian Wong, Kelvin Wong, Winnie C W Chu, Yunyun Xiong, Anne Y Y Chan, Timothy C Y Kwok, Xintao Hu, W K Lee, Wai-kwong Tang, Ka-sing Lawrence Wong, and Stephen Wong.
    • Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China. vctmok@cuhk.edu.hk
    • Dement Geriatr Cogn Disord. 2010 Jan 1;30(3):254-60.

    Background/AimsThis study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH).MethodsThe Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms.ResultsSeventy-seven stroke patients (mean WMH volume: 39.5 cm(3)) were recruited. Thirty patients (39%) had ≥ 1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression.ConclusionExecutive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.Copyright © 2010 S. Karger AG, Basel.

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