• J Clin Anesth · Sep 2007

    Randomized Controlled Trial

    Evaluation of low-dose propofol preadministration to attenuate vascular pain during induction of anesthesia.

    • Mitsuharu Kodaka, Shin-Ichiro Okuyama, Akihiko Maeyama, Kaoru Koyama, and Hideki Miyao.
    • Department of Anesthesiology, Saitama Medical Center, Saitama Medical School, Saitama, 350-8550, Japan. kmkodaka@cb3.so-net.ne.jp
    • J Clin Anesth. 2007 Sep 1;19(6):440-3.

    Study ObjectiveTo determine whether a small dose of propofol before induction decreases pain with injection using two different formulas of propofol-10% long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) and LCT.DesignProspective, randomized, comparative study.SettingUniversity-affiliated hospital.Patients200 ASA physical status I and II patients.InterventionsGroup A (LCT control) and group B (MCT/LCT control) were first preadministered normal saline plus Intralipid (Otsuka Pharmaceutical Co, Ltd, Tokyo, Japan) as a placebo, whereas group C (LCT study) and group D (MCT/LCT study) received each formulation of propofol 0.1 mg/kg before induction. After three minutes, groups A and C received LCT propofol two mg/kg for induction. Groups B and D received LCT/MCT propofol in the same manner.MeasurementPain was evaluated blindly at the time of both preadministration and induction, using a 4-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain.Main Results36 (72%) LCT and 31 (62%) LCT/MCT control group patients (groups A and B) had pain. Pretreatment with propofol (groups C and D) attenuated the frequency of pain significantly in 21 (42%) and 24 (48%) patients at induction, respectively.ConclusionLong-chain triglyceride and LCT/MCT propofol, 0.1 mg/kg administration before induction, resulted in attenuated pain at an induction dose of propofol.

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