• Ruyin Liu, Zongjin Yue, Xiaoyan Peng, Xinli Wang, Zhongkai Feng, and Long Wan.
• *Department of Spine, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China †Nursing Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China ‡Department of Orthopedics, Luohe Wuyang County Chinese Medicine Hospital, Luohe 462400, China.
• Spine. 2016 May 1; 41 (10): E618E624E618-24.

Study DesignWe investigated the association between ICAM-1, -2, -3 plasma levels and ankylosing spondylitis (AS) disease activity.ObjectiveIn the present study, we aimed to investigate the association between ICAM-1, -2, -3 plasma levels and AS disease activity in the Chinese Han population.Summary Of Background DataAS is a chronic inflammatory rheumatic disease that effects the sacroiliac joints and axial skeleton. The intercellular adhesion molecules (ICAMs) are members of the immunoglobulin superfamily and have been identified to play major roles in inflammation and immune responses.MethodsA total of 60 patients with AS and 60 healthy individuals were selected. The plasma levels of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and ICAM-1, -2, -3, were analyzed by ELISA. Disease severity-related indexes, including the Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), and ankylosing spondylitis disease activity score (ASDAS), were assessed, along with the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level.ResultsBoth ICAM-1 and ICAM-2 levels in plasma were markedly increased in AS patients compared with levels in the plasma of controls. There was no difference between controls and patients in term of ICAM-3 levels. Furthermore, in patients, correlation analysis showed that TNF-α and IL-6 production, as well as the ESR and CRP levels, have positive relationships with ICAM-1 and ICAM-2 plasma levels; the BASDAI, BASFI, and ASDAS scores were also found to be positively correlated with ICAM-2. However, no significant correlations between ICAM-1 levels and BASDAI, BASFI, or ASDAS were detected in our study.ConclusionThe current findings suggest that ICAM-2 may be a potential biomarker reflecting disease activity and functional ability in AS patients.Level Of Evidence5.

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