• Der Schmerz · Oct 2009

    Case Reports

    [Successful treatment of treatment-resistant opioid-induced constipation in a patient with incomplete paraplegia with methylnaltrexone].

    • E A Lux.
    • Klinik für Schmerz- und Palliativmedizin, Klinikum St.-Marien-Hospital, Altstadtstr.23, 44534 Lünen. drlux@web.de
    • Schmerz. 2009 Oct 1;23(5):523-4.

    AbstractWe observed a patient with incomplete, cervical paraplegia and opioid-induced constipation who developed a resistance to laxatives after 15 years of treatment. The constipation-induced reduction in the patient's quality of life was improved using 12 mg methylnaltrexone, a peripheral mu-opioid receptor antagonist, administered subcutaneously twice a week.

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