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Randomized Controlled Trial Multicenter Study Clinical Trial
Efficacy of microfiltration in decreasing propofol-induced pain.
- A F Davies, B Vadodaria, B Hopwood, T Dexter, and D Conn.
- Department of Anaesthesia, Royal Devon and Exeter Hospital, Exeter UK.
- Anaesthesia. 2002 Jun 1;57(6):557-61.
AbstractIn a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain. We studied 336 unpremedicated adult patients, who graded pain experienced during induction of anaesthesia with propofol on a 4-point verbal rating scale. Use of the microfilter reduced both the incidence and severity of propofol injection pain (p < 0.001). Incidence of severe pain in the filter group was 2.4% compared with 16.6% in the control group. Overall, 33.7% in the filter group experienced pain compared with 62.1% in the control group. A microbiological filter may provide a non-pharmacological alternative to a lidocaine/propofol mixture for reducing injection pain. It would also reduce the risk of any glass and bacterial contamination.
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