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Randomized Controlled Trial
The effect of positive end expiratory pressure on the respiratory profile during one-lung ventilation for thoracotomy.
- L M C Leong, S Chatterjee, and F Gao.
- Department of Anaesthesia, Alexandra Hospital, Redditch B98 7UB, UK. lucyleong@hotmail.com
- Anaesthesia. 2007 Jan 1;62(1):23-6.
AbstractSummary In this randomised controlled trial we examined the effects of four different levels of positive end expiratory pressure (PEEP at 0, 5, 8 or 10 cmH(2)O), added to the dependent lung, on respiratory profile and oxygenation during one lung ventilation. Forty-six patients were recruited to receive one of the randomised PEEP levels during one lung ventilation. We did not find significant differences in lung compliance, intra-operative or postoperative oxygenation amongst the four different groups. However, the physiological deadspace to tidal volume ventilation ratio was significantly lower in the 8 cmH(2)O PEEP group compared with the other levels of PEEP (p < 0.0001). We concluded that the use of PEEP (< or =10 cmH(2)O) during one lung ventilation does not clinically improve lung compliance, intra-operative or postoperative oxygenation despite a statistically significant reduction in the physiological deadspace to tidal volume ratio.
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