• Anaesthesia · Oct 1990

    Clinical presentation of suspected malignant hyperthermia during anaesthesia in 402 probands.

    • F R Ellis, P J Halsall, and A S Christian.
    • University Department of Anaesthesia, St. James's University Hospital, Leeds.
    • Anaesthesia. 1990 Oct 1;45(10):838-41.

    AbstractAs anaesthetists have become more aware of malignant hyperthermia the mortality rate has fallen, but concommitantly the number of dubious and aborted cases has increased. All probands who developed a suspected malignant hyperthermia reaction during anaesthesia and subsequently underwent muscle biopsy were classified according to the clinical presentation. A probability for malignant hyperthermia can be calculated, using the classification, for each type of clinical presentation; this varied from 0.96 to 0.07. Certain clinical features were found to be of more value as predictors than others; these included a high creative kinase and myoglobinuria. The accuracy of prediction depends on a clear contemporaneous description of the clinical events.

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