• J Pain Symptom Manage · Jun 2003

    Case Reports

    Olanzapine as an antiemetic in refractory nausea and vomiting in advanced cancer.

    • Manish Srivastava, Norman Brito-Dellan, Mellar P Davis, Marie Leach, and Ruth Lagman.
    • The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
    • J Pain Symptom Manage. 2003 Jun 1; 25 (6): 578582578-82.

    AbstractNausea and vomiting are difficult symptoms to manage in patients with advanced cancer. Several classes of antiemetics are available, including phenothiazines, butyrophenones, substituted benzamides and selective serotonin antagonists, as well as corticosteroids. Most patients will respond to either single agents or combinations that frequently include corticosteroids. A minority of patients will have nausea that fails to respond. The atypical antipsychotic, olanzapine, relieves nausea in some patients failing to respond to the usual antiemetics. Two case reports are presented and the rationale for olanzapine's benefit is discussed.

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