• Bryan Lieber, ByoungJun Han, Russell G Strom, Jeffrey Mullin, Anthony K Frempong-Boadu, Nitin Agarwal, Noojan Kazemi, and Monir Tabbosha.
• Department of Neurosurgery, University of Arkansas, Little Rock, Arkansas, USA.
• World Neurosurg. 2016 May 1; 89: 517-24.

BackgroundSurgical-site infections (SSIs) are a major cause of morbidity and mortality, increasing the length and cost of hospitalization. In patients undergoing spine surgery, there are limited large-scale data on patient-specific risk factors for SSIs.MethodsThe American College of Surgeons National Surgical Quality Improvement Program database was reviewed for all spinal operations between 2006 and 2012. The rates of 30-day SSIs were calculated, and univariate analysis of selected preoperative risk factors was performed. Multivariate analysis was then used to identify independent predictors of SSIs.ResultsA total of 1110 of the 60,179 patients (1.84%) had a postoperative wound infection. There were 527 (0.87%) deep and 590 (0.98%) superficial infections. Patients with infections had greater rates of sepsis, longer lengths of stay, and more return visits to the operating room. Independent predictors of infection were female sex, inpatient status, insulin-dependent diabetes, preoperative steroid use greater than 10 days, hematocrit less than 35, body mass index greater than 30, wound class, American Society of Anesthesiologists class, and operative duration.ConclusionsAnalysis of a large national patient database revealed many independent risk factors for SSIs after spinal surgery. Some of these risk factors can be modified preoperatively to reduce the risk of postoperative infection.Copyright © 2016 Elsevier Inc. All rights reserved.

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