• J D Lalau, M L Azzoug, F Kajbaf, C Briet, and R Desailloud.
• Service d'endocrinologie et de nutrition, hôpital Sud, centre hospitalier universitaire, 80054 Amiens cedex 1, France; Unité INSERM 1088, Université de Picardie-Jules-Verne, Amiens, France. Electronic address: lalau.jean-daniel@chu-amiens.fr.
• Diabetes Metab. 2014 Jun 1;40(3):220-3.

AimThese case reports demonstrate that, at the individual level, blood metformin concentrations and metformin effects on lactate do not always correlate.MethodsWe report here on two unusual cases: metformin accumulation in the absence of hyperlactataemia; and metformin-induced hyperlactataemia with no metformin accumulation.ResultsPatient #1 presented with severe kidney failure, severe acidosis (pH: 7.04), normal lactataemia (0.90 mmol/L) and marked metformin accumulation. Patient #2 presented with hyperlactataemia, even after dose reduction, during otherwise well-tolerated metformin treatment. Arterial lactate levels were 8.8, 8.2 and 4.7 mmol/L during metformin therapy with daily doses of 2550, 1700 and 850 mg, respectively. After withdrawal, metformin was reintroduced for 5-day periods at 500 mg/day up to 2000 mg/day with washout intervals. Lactate concentration, normal at baseline, rapidly exceeded 2 mmol/L after metformin administration.ConclusionThese clinical data suggest a new concept for metformin therapy: there may be either resistance or, conversely, hypersensitivity to metformin effects on lactate generation according to the individual patient.Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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