Diabetes & metabolism
The most recent articles from:
June 2014
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Diabetes & metabolism · Jun 2014
Case ReportsMetformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation.
These case reports demonstrate that, at the individual level, blood metformin concentrations and metformin effects on lactate do not always correlate. ⋯ These clinical data suggest a new concept for metformin therapy: there may be either resistance or, conversely, hypersensitivity to metformin effects on lactate generation according to the individual patient.