• Anaesthesia · Aug 2002

    Randomized Controlled Trial Clinical Trial

    Effect of pre-operative anxiolysis on postoperative pain response in patients undergoing total abdominal hysterectomy.

    • W Caumo, M P L Hidalgo, A P Schmidt, C W Iwamoto, L C Adamatti, J Bergmann, and M B C Ferreira.
    • Anaesthesia Service, Hospital de Clínicas de Port Alegre, Universidade Federal do Rio Grande do Sul, UFRGS, Brazil. caumo@cpovo.net
    • Anaesthesia. 2002 Aug 1;57(8):740-6.

    AbstractIn a double blind, placebo-controlled trial, we have assessed the effects of pre-operative anxiolysis on postoperative pain scores in 112 ASA I-II women, aged 18-65 years, scheduled to undergo total abdominal hysterectomy. Subjects were randomly allocated to receive either oral diazepam 10 mg (n=56) or placebo (n=56) pre-operatively. Postoperative anxiety, pain scores, analgesic consumption, and sedation were evaluated at several time points during the first 24 h following surgery. Postoperative pain scores were found to be significantly higher in the diazepam group. Trait and state anxiety showed a significant effect on pain scores, independent of the treatment group. No difference was found between the groups in morphine consumption, but there was a significant reduction in morphine consumption with time.

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