• A Foinard, B Décaudin, C Barthélémy, G Lebuffe, B Debaene, and P Odou.
• Department of Biopharmacy, Galenic and Hospital Pharmacy, Lille 2 University, UDSL, EA GRIIOT, UFR Pharmacie, Lille, France.
• Anaesthesia. 2014 Feb 1;69(2):131-6.

AbstractThe aim of our in-vitro study was to assess the impact of infusion set characteristics on the accuracy of morphine doses in patient-controlled analgesia. Two infusion sets differing in conception and dead-space volume were assessed: a standard set and a low dead-space volume Y-set. The patient-controlled analgesia programme parameters were as follows: bolus equal to 1 ml at 100 ml.h(-1) ; lockout intervals equal to 5 and 10 min; and carrier fluid flow rate equal to 10 and 50 ml.h(-1) . Morphine concentration was determined by an ultraviolet spectrophotometric method. The morphine doses were significantly different from one set to the other during bolus and lockout intervals, whatever the patient-controlled analgesia programme. The average doses were approximately 1.3-6.0 times higher with the low dead-space volume Y-set during bolus. Our study underlines the impact of infusion set characteristics on the accuracy of morphine patient-controlled analgesia doses.© 2013 The Association of Anaesthetists of Great Britain and Ireland.

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