• Ann. Thorac. Surg. · Feb 2004

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Off-pump versus on-pump myocardial revascularization in low-risk patients with one or two vessel disease: perioperative results in a multicenter randomized controlled trial.

    • Luís Roberto Gerola, Enio Buffolo, Waldir Jasbik, Bruno Botelho, João Bosco, Luís A Brasil, and João Nelson R Branco.
    • Division of Cardiovascular Surgery, Department of Surgery, Federal University of São Paulo Brasil, Sao Paolo, Brazil. gerola@uol.com.br
    • Ann. Thorac. Surg. 2004 Feb 1;77(2):569-73.

    BackgroundTo evaluate hospital mortality and morbidity after myocardial revascularization in a prospective and multicenter study, comparing on-pump versus off-pump in a special subset of patients with lesions in the left descending artery, alone or associated with the right coronary artery.MethodsA multicenter prospective randomized study was performed. One hundred and sixty selected low-risk patients were enrolled; 80 patients were operated on-pump (coronary artery bypass grafting [CABG], group I) and 80 patients were operated off-pump (off-pump coronary artery bypass [OPCAB], group II). One hundred and five were male and ages ranged from 39 to 70 years old; mean 58.81 +/- 9.31 and median 59. Preoperative clinical characteristics were similar in both groups; only previous myocardial infarction was higher in the OPCAB group. Patients with severe left ventricular dysfunction (FE ResultsHospital mortality was 2.5%, three patients (3.7%) in group I (on-pump) and one patient (1.2%) in group II (off-pump) (ns). The number of grafts per patients in group I was 1.81 +/- 0.6, and 1.77 +/- 0.68 in group II (p = 0.833). There was no difference in the total operation time 205.10 +/- 54.30 minutes in group I and 189.50 +/- 55.44 in group II (ns). Six patients (7.5%) had myocardial infarction in group I and three (3.7%) in group II (ns). Bleeding in the postoperative period was 680.50 +/- 434.1 mL in the on-pump group and 678.6 +/- 357.0 mL in the off-pump group (ns). Three patients (3.7%) presented transient neurologic dysfunction in group I and six patients (7.5%) in group II (ns). Intensive care stay was 2.4 +/- 1.0 days in the CABG and 2.3 +/- 0.98 days in the OPCAB group (ns).ConclusionsWe did not find any statistical difference in hospital mortality and morbidity using on-pump or off-pump techniques for low-risk patients.

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