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          Randomized Controlled TrialDo preparation and life completion discussions improve functioning and quality of life in seriously ill patients? Pilot randomized control trial.- Karen E Steinhauser, Stewart C Alexander, Ira R Byock, Linda K George, Maren K Olsen, and James A Tulsky.
- Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, North Carolina 27705, USA. Karen.steinhauser@duke.edu
- J Palliat Med. 2008 Nov 1;11(9):1234-40.
 BackgroundSignificant palliative care intervention has focused on physical pain and symptom control; yet less empirical evidence supports efforts to address the psychosocial and spiritual dimensions of experience.ObjectiveTo evaluate the impact of an intervention (Outlook) that promotes discussions of end-of-life preparation and completion on health outcomes in dying persons, including pain and symptoms, physical function, emotional function (anxiety and depression), spiritual well-being, and quality of life at the end of life.DesignA three-arm pilot randomized control trial. Subjects were recruited from inpatient and outpatient hospital, palliative care, and hospice settings. Intervention subjects met with a facilitator three times and discussed issues related to life review, forgiveness, and heritage and legacy. Attention control subjects met with a facilitator three times and listened to a nonguided relaxation CD. True control subjects received no intervention.MeasurementsPreoutcomes and postoutcomes included the Memorial Symptom Assessment Scale, QUAL-E, Rosow-Breslau ADL Scale, Profile of Mood States anxiety sub-scale, the CESD short version, and the Daily Spiritual Experience Scale.ResultsEighty-two hospice eligible patients enrolled in the study; 38 were women, 35 were African American. Participants' primary diagnoses included cancer (48), heart disease (5) lung disease (10), and other (19) Ages ranged from 28-96. Participants in the active discussion intervention showed improvements in functional status, anxiety, depression, and preparation for end of life.ConclusionsThe Outlook intervention was acceptable to patients from a variety of educational and ethnic backgrounds and offers a brief, manualized, intervention for emotional and spiritual concerns. Notes
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