• Anaesthesia · Sep 2004

    Randomized Controlled Trial Clinical Trial

    A partially blinded randomised controlled trial of patient-maintained propofol sedation and operator controlled midazolam sedation in third molar extractions.

    • J A Leitch, K Anderson, S Gambhir, K Millar, N D Robb, S McHugh, and G N C Kenny.
    • University of Glasgow Dental School, 378 Sauchiehall Street, Glasgow, G2 3JZ, UK. leitch@bigfoot.com
    • Anaesthesia. 2004 Sep 1;59(9):853-60.

    AbstractPatient-maintained sedation using propofol has recently been shown to be effective for dental surgery. We compared this new technique to the established technique of operator administered midazolam. The two groups were compared before, during and after sedation. The two primary outcomes were time until discharge and oxygen saturation. Vital signs, anxiety and psychomotor skills were also compared. State anxiety was reduced to a greater extent in the propofol group (mean difference 10 (SD 4) mm; p = 0.010. Propofol patients recovered quicker (mean difference 7 (SD 1.4) min; p = 0.001). Propofol patients had a smaller reduction in arterial oxygen saturation (mean difference 0.8 (SD 0.3)%; p = 0.030), and a reduced increase in heart rate (mean difference 9 (SD 2) beats.min(-1); p < 0.001). Both techniques were well tolerated and safe. Propofol sedation offered superior anxiolysis, quicker recovery, less amnesia and less depression of simple psychomotor function.

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