Peri-operative melatonin may cause small reductions in pre-operative anxiety and post-operative pain.

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• L P H Andersen, M U Werner, J Rosenberg, and I Gögenur.
• Department of Surgery D, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
• Anaesthesia. 2014 Oct 1; 69 (10): 1163-71.

AbstractWe systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements. © 2014 The Association of Anaesthetists of Great Britain and Ireland.

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