• Br J Anaesth · Dec 2014

    Randomized Controlled Trial Multicenter Study Observational Study

    Association between intraoperative electroencephalographic suppression and postoperative mortality.

    • M Willingham, A Ben Abdallah, S Gradwohl, D Helsten, N Lin, A Villafranca, E Jacobsohn, M Avidan, and H Kaiser.
    • Department of Anesthesiology, Washington University in St Louis School of Medicine, Campus Box 8054, 660 S. Euclid Ave., St Louis, MO 63110, USA.
    • Br J Anaesth. 2014 Dec 1;113(6):1001-8.

    BackgroundLow bispectral index values frequently reflect EEG suppression and have been associated with postoperative mortality. This study investigated whether intraoperative EEG suppression was an independent predictor of 90 day postoperative mortality and explored risk factors for EEG suppression.MethodsThis observational study included 2662 adults enrolled in the B-Unaware or BAG-RECALL trials. A cohort was defined with >5 cumulative minutes of EEG suppression, and 1:2 propensity-matched to a non-suppressed cohort (≤5 min suppression). We evaluated the association between EEG suppression and mortality using multivariable logistic regression, and examined risk factors for EEG suppression using zero-inflated mixed effects analysis.ResultsNinety day postoperative mortality was 3.9% overall, 6.3% in the suppressed cohort, and 3.0% in the non-suppressed cohort {odds ratio (OR) [95% confidence interval (CI)]=2.19 (1.48-3.26)}. After matching and multivariable adjustment, EEG suppression was not associated with mortality [OR (95% CI)=0.83 (0.55-1.25)]; however, the interaction between EEG suppression and mean arterial pressure (MAP) <55 mm Hg was [OR (95% CI)=2.96 (1.34-6.52)]. Risk factors for EEG suppression were older age, number of comorbidities, chronic obstructive pulmonary disease, and higher intraoperative doses of benzodiazepines, opioids, or volatile anaesthetics. EEG suppression was less likely in patients with cancer, preoperative alcohol, opioid or benzodiazepine consumption, and intraoperative nitrous oxide exposure.ConclusionsAlthough EEG suppression was associated with increasing anaesthetic administration and comorbidities, the hypothesis that intraoperative EEG suppression is a predictor of postoperative mortality was only supported if it was coincident with low MAP.Clinical Trial RegistrationNCT00281489 and NCT00682825.© The Author [2014]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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    This article appears in the collection: Postoperative mortality and intraoperative anesthetic depth.


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