• Rev Actual Estomatol Esp · Jan 1989

    Historical Article

    [Local anesthetics (LA). Introduction (1)].

    • S Rubio Alonso, C Burgos Sanchez-Escribano, and A J Chaparro Heredia.
    • Rev Actual Estomatol Esp. 1989 Jan 1;49(380):29-30, 33-4.

    AbstractA brief historical review of man's attempts to produce pain relief is presented, from physical measures: compression, application of cold, to anesthetic gases and up to the introduction of cocaine and its synthetic derivatives. These offer us now a wide range of drugs with characteristics and properties of local anesthetics which are more and more effective and at the same time with fewer undesirable side effects.

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