• Anesthesiology · Apr 1982

    Comparative Study

    Different laryngeal responses during respiratory arrest produced by hypoxia withdrawal, thiopentone, ketamine, and lidocaine in cats.

    • T Nishino, T Yonezawa, and Y Honda.
    • Anesthesiology. 1982 Apr 1;56(4):280-5.

    AbstractThe changes in laryngeal resistance (LR) during respiratory arrest produced by withdrawal of hypoxia stimulation and administration of various respiratory depressants were studied in 14 spontaneously breathing, anesthetized cats (11 cats with alpha-chloralose and three cats with halothane). Withdrawal of hypoxia stimulation caused a transient respiratory arrest with no central inspiratory activity, during which a considerable increase in LR was observed to a level higher than the fixed resistance after muscle paralysis [LR(fix)]. Intravenous injection of thiopentone, ketamine, and lidocaine all caused a transient respiratory arrest. However, the effects on the laryngeal function and the central inspiratory activity were different for each agent. Both thiopentone and ketamine induced an inspiratory apneusis pattern in phrenic nerve discharge, and lidocaine caused a silence of phrenic nerve activity. Thiopentone relaxed the larynx, and LR during thiopentone-induced respiratory arrest was almost equal to LR(fix). Ketamine maintained a dilatation of the larynx, and LR during ketamine-induced respiratory arrest was lower than LR(fix). Lidocaine caused a constriction of the larynx and LR greatly increased, leading frequently to laryngospasm. These results indicate that hypoxia withdrawal, thiopentone, ketamine, and lidocaine all cause different effects on the central inspiratory activity, and that the central respiratory depression produced by these methods is not accompanied by a uniform depression of laryngeal function.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…