• Anaesthesia · Aug 2003

    Randomized Controlled Trial Clinical Trial

    Effect of supplemental pre-operative fluid on postoperative nausea and vomiting.

    • S Z Ali, A Taguchi, B Holtmann, and A Kurz.
    • Division of Critical Care Medicine, Department of Anaesthesiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8054, St. Louis, MO 63110, USA.
    • Anaesthesia. 2003 Aug 1;58(8):780-4.

    AbstractIn a prospective, double-blind, randomised controlled trial, we studied the effects of pre-operative fluid load on post-operative nausea and vomiting. Eighty patients attending for laparoscopic cholecystectomy or gynaecological surgery were randomly allocated to receive 2 ml.kg-1 (conservative) or 15 ml.kg-1 (supplemental) Hartmann's solution intravenously, shortly before induction of anaesthesia. During the operation, fluid management was identical in both groups. During the first post-operative 24 h, post-operative nausea and vomiting occurred in 29 patients (73%) in the conservative fluid group and nine patients (23%) in the supplemental fluid group (p = 0.01). Supplemental pre-operative fluid is an inexpensive and safe therapy for reducing post-operative nausea and vomiting.

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