-
- M I Gold, D Abello, and C Herrington.
- University of Miami School of Medicine, Department of Anesthesiology, Florida 33125.
- Anesthesiology. 1993 Oct 1;79(4):710-4.
BackgroundThe minimum alveolar concentration (MAC) of desflurane/oxygen is 7.25% in the 18-30-yr age group, and 6.0% in the 31-65-yr age group. The addition of 60% N2O reduces MAC to 4.0 and 2.83%, respectively. Because MAC of other inhaled anesthetics is less than that for younger adults, we determined MAC of desflurane in adults aged 65 yr and older.MethodsThirty-nine patients, 21 of whom received 60% N2O/O2/desflurane, and 18 of whom received desflurane/oxygen, scheduled for surgery, were enrolled. They received no premedication, intravenous induction agent, opioid, or neuromuscular blocking agent for intubation. After 10 min or more at a steady end-tidal desflurane concentration, the incision was made. In both groups, six crossover pairs of patients responses (movement-no movement) provided a mean end-tidal concentration. Minimum alveolar concentration was defined as the average of the six crossover midpoints in each subgroup.ResultsMAC was 5.17 +/ 0.6% (mean +/- SD) in the desflurane/oxygen group. It was 1.67 +/- 0.4% in the desflurane/nitrous oxide/oxygen group.ConclusionsIn the geriatric patient, MAC of desflurane, with or without nitrous oxide, is less than that reported in patients aged 18-65 yr. This is in agreement with results with all other inhalation agents.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.