• Yue Zhang, Shi Zhang, Xiaoping Chen, and Shixing Hu.
• Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
• Yan Ke Xue Bao. 2006 Sep 1;22(3):202-6.

PurposeTo investigate the effect and the best concentration of Tetrandrine (Tet) eye drops in inhibition of the corneal allograft rejection in rat.MethodsEighty SD rats were randomly divided for being treated with 0.3%, 0.5%, 1.0% Tetrandrine eye drops, respectively. 0.1% Dexamethasone eye drops-treated and control groups. After the rat model of heterograft-heterotopic graft rejection was made, slit-limp microscope and HE staining, light microscope and microphoto-analyses technique were used to observe the neovascular formation and inflammation at different time points at post-operation.ResultsThe types of the cells in the surgical area were mainly lymphocytes and mononuclear-macrophage. Corneal neovascularization and inflammatory cells were significantly inhibited in 0.5% Tetrandrine eye drops-treated group (P < 0.05), compared with control group at 7 d, 14 d, 21 d, 28 d post-operation.ConclusionsThe results indicate that 0.5% Tet eye drops significantly inhibit the corneal allograft rejection in rats without obvious side effects.

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