• Anaesthesia · Mar 1991

    Randomized Controlled Trial Comparative Study Clinical Trial

    Epidural infusion of diamorphine with bupivacaine in labour. A comparison with fentanyl and bupivacaine.

    • G R Enever, H A Noble, D Kolditz, S Valentine, and T A Thomas.
    • Department of Anaesthesia, Bristol Maternity Hospital.
    • Anaesthesia. 1991 Mar 1;46(3):169-73.

    AbstractWe have compared the analgesic effects of three epidural infusions in a randomised, double-blind study of 61 mothers in labour. An initial dose of bupivacaine 0.5% 8 ml was followed by either bupivacaine 0.125%, bupivacaine 0.125% with diamorphine 0.0025% or bupivacaine 0.125% with fentanyl 0.0002%. All infusions were run at a rate of 7.5 ml/hour. Analgesia was significantly better in both the groups receiving opioids. Diamorphine was shown to be the more effective supplement to bupivacaine. The 5% incidence of pruritus in the opioid groups was less than that reported by earlier authors.

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