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- S J Watt, L B Cook, S Ohri, and G G Lockwood.
- Department of Anaesthetics, Hemel Hempstead General Hospital, Herts.
- Anaesthesia. 1996 Jan 1;51(1):24-8.
AbstractThe hypothesis that anaesthetic uptake during maintenance of anaesthesia is related to cardiac output was tested on 21 patients undergoing cardiac surgery. Using a computer-controlled closed breathing system, enflurane was administered to maintain an end-expired concentration of 1%. Cardiac output was measured by thermodilution using a pulmonary artery catheter. A clear qualitative but not quantitative relationship was demonstrated. Changes in anaesthetic requirements at a constant end-expired concentration are a better guide to changes in cardiac output than changes in end-expired carbon dioxide with constant ventilation in patients undergoing cardiac surgery.
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