• Dilnasheen Meerza, Sarah Iqbal, Sufian Zaheer, and Imrana Naseem.
• Department of Biochemistry, Aligarh Muslim University, Aligarh, India.
• Nutrition. 2016 Jul 1; 32 (7-8): 898-903.

ObjectiveUncontrolled diabetes is associated with a compromised antioxidant state of the body. Consequentially, the reactive oxygen species generated lead to oxidative insult and associated complications. Based on this paradigm, exogenous antioxidant supplementation is thought to exert a therapeutic role in type 2 diabetes (T2-D) biology.MethodsIn the present study, the effect of vitamin A supplementation was assessed on disease progression in T2-D BALB/c mice. Animals were divided into three groups. With the exception of control, the mice in remaining groups were induced with experimental T2-D. After a 15-day treatment protocol, the mice were sacrificed and various parameters were analyzed.ResultsThe treated group evidenced a considerable improvement in total antioxidant potential and glycemic control. A therapeutic effect on beta cell degeneration as compared to the diabetic group was also found.ConclusionsThe study illustrates the antihyperglycemic and antioxidant potential of vitamin A in vivo, which has potential to serve as a dietary intervention in T2-D.Copyright © 2016 Elsevier Inc. All rights reserved.

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