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- M Fisher, M B Zawadzki, S Ameriso, F Quismorio, V Wong, J Bernard, C S Zee, and A Paganini-Hill.
- Department of Neurology USC School of Medicine.
- J Neuroimaging. 1993 Jan 1; 3 (1): 28-32.
AbstractMagnetic resonance imaging (MRI) findings in a group of 60 ambulatory elderly individuals (average age, 75.8 yr) were characterized as normal (grade 0), periventricular changes only (grade 1 ). small punctate lesions (grade 2), and confluent or large (> 2 mm) punctate lesions (grade 3). Patients were characterized by stroke risk factors, cardiolipin antibodies, coagulation factors (fibrinogen and plasminogen activator inhibitor-1 ). and Doppler ultrasound findings in the carotid and middle cerebral arteries. Subcortical signal abnormalities were present in 62% (37 /60), relatively evenly distributed between grade 1 (18%), grade 2 (25%), and grade 3 (18%). There was no significant association between variables and MRI grade. These findings suggest that ischemia is not a major cause of MRI signal abnormalities in neurologically asymptomatic elderly individuals.Copyright © 1993 by the American Society of Neuroimaging.
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