• Anaesthesia · Jan 1991

    Randomized Controlled Trial Comparative Study Clinical Trial

    Modification of pain on injection of propofol--a comparison between lignocaine and procaine.

    • M E Nicol, J Moriarty, J Edwards, D S Robbie, and R P A'Hern.
    • Royal Marsden Hospital, London.
    • Anaesthesia. 1991 Jan 1; 46 (1): 67-9.

    AbstractPain on injection of propofol was assessed in a controlled, randomised study of 273 patients. They received either lignocaine 10 mg, procaine 10 mg or isotonic saline 0.5 ml, 15 seconds before the injection of propofol into a vein on the back of the hand. The incidence of pain on injection in the control group (51%) was comparable with other studies. Lignocaine and procaine both significantly reduced the pain (35% and 34% respectively, p less than 0.05) but there was no statistical difference between these two groups.

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