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Randomized Controlled Trial Clinical Trial
Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India.
- Lakshmi Rahmathullah, James M Tielsch, R D Thulasiraj, Joanne Katz, Christian Coles, Sheela Devi, Rajeesh John, Karthik Prakash, A V Sadanand, N Edwin, and C Kamaraj.
- Aravind Centre for Women, Children and Community Health, Madurai, Tamil Nadu, India.
- BMJ. 2003 Aug 2; 327 (7409): 254.
ObjectiveTo assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.DesignCommunity based, randomised, double blind, placebo controlled trial.SettingTwo rural districts of Tamil Nadu, southern India.Participants11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.Main Outcome MeasurePrimary outcome measure was mortality at age 6 months.ResultsInfants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.ConclusionSupplementing newborn infants with vitamin A can significantly reduce early infant mortality.
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