• Dement Geriatr Cogn Disord · Jan 2008

    The extended tau haplotype and the age of onset of dementia in Down syndrome.

    • Emma L Jones, Marisa Margallo-Lana, Vee P Prasher, and Clive G Ballard.
    • Wolfson Centre for Age-Related Disease, Guy's Campus, King's College London, London, UK. emma.3.jones@kcl.ac.uk
    • Dement Geriatr Cogn Disord. 2008 Jan 1; 26 (3): 199-202.

    Background/AimsMost people with Down syndrome (DS) develop Alzheimer's disease (AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS.MethodsPeople with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8).ResultsHaplotype frequencies vary between those developing AD before 45 and those developing dementia after this age (p = 0.03). H1/H2 individuals are more likely to develop dementia before 45 than H1/H1 individuals (OR = 3, 95% CI = 1.01-8.91).ConclusionEven in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets.Copyright 2008 S. Karger AG, Basel.

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