• Resuscitation · Dec 2015

    Review

    Animal studies of neonatal hypothermic neuroprotection have translated well in to practice.

    • Alistair J Gunn and Marianne Thoresen.
    • Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag, 92019 Auckland, New Zealand. Electronic address: aj.gunn@auckland.ac.nz.
    • Resuscitation. 2015 Dec 1; 97: 88-90.

    AbstractThe discovery that mild, induced hypothermia can improve neurological recovery after global moderate to severe hypoxia-ischemia has been a dramatic validation of the strong foundation of preclinical studies that informed current protocols. The major challenge is to find ways to further improve outcomes. As discussed in this review, the findings from large clinical trials of extended cooling are highly concordant with recent animal studies. These findings support the use of precise, carefully selected animal models to refine our strategies to protect babies with moderate to severe encephalopathy before instigating further large trials. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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