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- Patrick Ray, Yannick Le Manach, Bruno Riou, and Tim T Houle.
- Department of Emergency Medicine and Surgery, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
- Anesthesiology. 2010 Apr 1; 112 (4): 1023-40.
AbstractA biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical interventions such as the use of drugs. Although considerable progress has been made in standardizing the methodology and reporting of randomized trials, less has been accomplished concerning the assessment of biomarkers. Biomarker studies are often presented with poor biostatistics and methodologic flaws that precludes them from providing a reliable and reproducible scientific message. A host of issues are discussed that can improve the statistical evaluation and reporting of biomarker studies. Investigators should be aware of these issues when designing their studies, editors and reviewers when analyzing a manuscript, and readers when interpreting results.
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