• Anaesthesia · Jan 1991

    Case Reports

    Response to suxamethonium in a myasthenic patient during remission.

    • M Abel, J B Eisenkraft, and N Patel.
    • Department of Anesthesiology, Mount Sinai Medical Center, New York, New York 10029-6574.
    • Anaesthesia. 1991 Jan 1; 46 (1): 30-2.

    AbstractA cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed myasthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08 mg/kg and 0.20 mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90-95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.

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