• J Trauma · Jul 2004

    Comparative Study

    Comparison of poly-N-acetyl glucosamine with commercially available topical hemostats for achieving hemostasis in coagulopathic models of splenic hemorrhage.

    • Steven D Schwaitzberg, Michele W Chan, David J Cole, Marjorie Read, Timothy Nichols, David Bellinger, and Raymond J Connolly.
    • Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA. sschwaitzberg@lifespan.org
    • J Trauma. 2004 Jul 1; 57 (1 Suppl): S29-32.

    BackgroundThe hemostatic quality of the poly-N-acetyl glucosamine (p-GlcNAc) patch was compared with a fibrin sealant, fibrin bandage, and cellulose patch.MethodsA 2 x 2-cm capsular strip to a depth of 3 mm of the swine spleen was used as a source of bleeding. Splenic lacerations were created in hemophilia B dogs and treated with p-GlcNAc and Surgicel. Wounds were created in rabbits and treated with p-GlcNAc at 37degreesC and after keeping body core temperature at 29degreesC.ResultsPoly-N-acetyl glucosamine was able to achieve hemostasis with greater efficacy than either of the fibrin-based bandages. In the hemophilia B dog study, p-GlcNAc significantly outperformed Surgicel, with p-GlcNAc achieving hemostasis in 75% of the treated wounds compared with 17% for the cellulose patch. The hypothermia study demonstrated that p-GlcNAc is equally effective at 29degreesC and at 37degreesC.ConclusionPoly-N-acetyl glucosamine was effective at controlling bleeding in animals with experimentally induced or genetic coagulopathic disorders.

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