• Anaesthesia · Jun 1984

    Case Reports

    Intracranial pressure after phenoperidine.

    • R M Grummitt and V A Goat.
    • Anaesthesia. 1984 Jun 1; 39 (6): 565-7.

    AbstractThe problem of sedating patients requiring prolonged controlled ventilation has recently received considerable attention. Various therapeutic regimes are available and there appears to be a general move away from the use of muscle relaxants towards sedative drugs. Phenoperidine is a popular agent for this purpose. One survey from a district general hospital reported that 66% of their ventilated intensive therapy unit patients received phenoperidine, either alone or as part of a sedation regime. However, enthusiasm for its use must be tempered by recent reports of cardiovascular collapse following its administration. We wish to report a case of intracranial hypertension following the use of phenoperidine in a ventilated patient with a severe head injury.

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