• Han Jo Kim, Sravisht Iyer, Luke P Zebala, Michael P Kelly, Daniel Sciubba, Themistocles S Protopsaltis, Munish Gupta, Brian J Neuman, Gregory M Mundis, Christopher P Ames, Justin S Smith, Robert Hart, Douglas Burton, Eric O Klineberg, and International Spine Study Group (ISSG).
• Hospital for Special Surgery, New York NY.
• Spine. 2017 Mar 15; 42 (6): 420-427.

Study DesignPrognostic study-case controlled.ObjectiveDescribe the rate of neurologic complications in adult spinal deformity surgery and describe the effect of these complications on clinical outcomes.Summary Of Background DataThe incidence of neurologic complications and the risk factors for neurologic complications have not been reported in a large series of patients with adult spinal deformity (ASD). Existing series include a mixed patient cohort undergoing different types of spine surgery.MethodsPatients with ASD undergoing surgery between 2008 and 2014 were analyzed. Patients with neurologic complications were identified; demographics, operative details, and radiographic and clinical outcomes were compared. A subanalysis of those with surgical and nonsurgical (e.g., stroke) neurologic complications was performed. Statistical analysis included t tests or χ tests as appropriate and a multivariate analysis. A P value of less than 0.025 was considered significant.ResultsA total of 564 patients met the inclusion criteria. The average age was 57 years. There were a total of 116 neurologic complications in 99 patients (17.6%). There were 88 surgical procedure-related neurologic complications in 77 patients (13.7%) and 28 nonsurgical neurologic complications in 28 patients (5.0%). The most common complications were radiculopathy (30%), motor deficits (22%), mental status changes (12%), and sensory deficits (12%). Revisions (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.2-2.4) and interbody fusions (OR 2.1, 95% CI 1.4-3.2) were associated with an increased risk of neurologic complications. Decompression and osteotomies (including three-column osteotomies) did not increase the risk of neurologic complications. Patients with neurologic complications were not more likely to sustain other complications; however, they were more likely to undergo another operation during the follow-up period (OR 1.9, 95% CI 1.3-2.8).ConclusionThe overall incidence of neurologic complications in ASD surgery was 17.6%. The incidence of surgical neurologic complications was 13.7%. There was a higher risk of neurologic complications in revision cases and in cases in which interbody fusion was required.Level Of Evidence3.

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