• Christian Jungreuthmayer, Stefan Neubauer, Teresa Mairinger, Jürgen Zanghellini, and Stephan Hann.
• Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria and.
• Bioinformatics. 2016 Jan 1; 32 (1): 154-6.

SummaryIsotope tracer experiments are an invaluable technique to analyze and study the metabolism of biological systems. However, isotope labeling experiments are often affected by naturally abundant isotopes especially in cases where mass spectrometric methods make use of derivatization. The correction of these additive interferences--in particular for complex isotopic systems--is numerically challenging and still an emerging field of research. When positional information is generated via collision-induced dissociation, even more complex calculations for isotopic interference correction are necessary. So far, no freely available tools can handle tandem mass spectrometry data. We present isotope correction toolbox, a program that corrects tandem mass isotopomer data from tandem mass spectrometry experiments. Isotope correction toolbox is written in the multi-platform programming language Perl and, therefore, can be used on all commonly available computer platforms.Availability And ImplementationSource code and documentation can be freely obtained under the Artistic License or the GNU General Public License from: https://github.com/jungreuc/isotope_correction_toolbox/Contact{christian.jungreuthmayer@boku.ac.at,juergen.zanghellini@boku.ac.at}Supplementary InformationSupplementary data are available at Bioinformatics online.© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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