• Guoquan Zheng, Kai Song, Ziming Yao, Yonggang Zhang, Xiangyu Tang, Zheng Wang, Xuesong Zhang, Keya Mao, Geng Cui, and Yan Wang.
• Department of Orthopedics, General Hospital of Chinese People's Liberation Army, Beijing, PR China.
• Spine. 2016 Sep 1; 41 (17): E1046-52.

Study DesignA prospective case series study.ObjectiveTo describe and assess a two-level osteotomy method for the management of severe thoracolumbar kyphosis (TLK) in patients with ankylosing spondylitis (AS).Summary Of Background DataTo achieve better postoperative outcomes in these patients, a sophisticated preoperative surgical plan is required. Most deformities are managed using a one-level osteotomy and a two-level osteotomy is seldomly reported. Till date, no study has described a two-level osteotomy for these cases.MethodsFrom January 2011 to December 2012, 10 consecutive patients with ankylosing spondylitis who underwent two-level spinal osteotomy were studied. Pre- and postoperative full-length free-standing radiographs, including the whole spine and pelvis, were available for all patients. Pre- and postoperative radiological parameters, including T5-S1 Cobb angles, TLK, lumbar lordosis, pelvic incidence, pelvic tilt, sacral slope, and sagittal vertical axis were measured. Health related quality of life , including Oswestry Disability Index and Scoliosis Research Society-22 surveys were administered before surgery and at 1-year follow up.ResultsThe preoperative and postoperative T5-S1 Cobb angles was 51.3° and -7.1°, respectively (P < 0.001). All patients demonstrated changes in postoperative radiographic parameters including decreased pelvic tilt (from 37.1° to 14.3°, P < 0.001), TLK (from 36.9° to 12.6°, P < 0.001), and sagittal vertical axis (from 21.4 cm to 7.1 cm, P < 0.001), increased lumbar lordosis (from -5.1° to -47.1°, P < 0.001), sacral slope (from 13.4° to 37.7°, P < 0.001), but no significant change in pelvic incidence. Health related quality of life scores at 1-year follow up were significantly improved compared to those before surgery.ConclusionThis calculation of two-level osteotomy provides an accurate and reproducible method for ankylosing spondylitis correction. By which, we can obtain satisfactory radiological parameters and clinical outcomes.Level Of Evidence4.

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