• Dimitrios Varvarousis, Giolanda Varvarousi, Nicoletta Iacovidou, Ernesto D'Aloja, Anil Gulati, and Theodoros Xanthos.
• Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: dvarvar@hotmail.com.
• Am J Emerg Med. 2015 Sep 1;33(9):1297-304.

BackgroundCardiac arrest is not a uniform condition and significant heterogeneity exists within all victims with regard to the cause of cardiac arrest. Primary cardiac (dysrhythmic) and asphyxial causes together are responsible for most cases of cardiac arrest at all age groups. The purpose of this article is to review the pathophysiologic differences between dysrhythmic and asphyxial cardiac arrest in the prearrest period, during the no-flow state, and after successful cardiopulmonary resuscitation.MethodsThe electronic databases of PubMed/Medline, Scopus, and Cochrane were searched for relevant literature and studies.Results/DiscussionSignificant differences exist between dysrhythmic and asphyxial cardiac arrest regarding their pathophysiologic pathways and affect consequently the postresuscitation period. Laboratory data indicate that asphyxial cardiac arrest leads to more widespread postresuscitation brain damage compared with dysrhythmic cardiac arrest. Regarding postresuscitation myocardial dysfunction, few studies have addressed a comparison of the 2 conditions with controversial results.ConclusionsAsphyxial cardiac arrest differs significantly from dysrhythmic cardiac arrest with regard to pathophysiologic mechanisms, neuropathologic damage, postresuscitation organ dysfunction, and response to therapy. Both conditions should be considered and treated in a different manner.Copyright © 2015 Elsevier Inc. All rights reserved.

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