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- Girish Thunga, Kishore Gnana Sam, Dipish Patel, Kanav Khera, Subha Sheshadhri, Shibu Bahuleyan, Rohit Vansalan, Vinay R Pandit, and Chetan Manohar.
- Department of Pharmacy Practice, SS Cancer Hospital and Research Center, Manipal College of Pharmaceutical Sciences, Manipal 576104, India.
- Am J Emerg Med. 2008 Nov 1; 26 (9): 1070.e1-4.
AbstractThe use of dapsone is increasing even though overdose is rarely reported and physicians must be aware of its toxicity and management. Mortality can occur due to methemoglobinemia and hemolytic anemia. Although activated charcoal and methylene blue are recommended, the use of hemodialysis is reported only in few studies. Literature on the kinetic profile indicates that 50% to 80% of dapsone is protein bound and indicates a possibility to dialyze the unbound form. This study describes a case of deliberate severe dapsone overdose with cyanosis, methemoglobinemia, and hemolytic anemia, which improved after repetitive hemodialysis.
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