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- Mark D Huffman, Angharad N de Cates, and Shah Ebrahim.
- Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
- JAMA. 2014 Nov 19;312(19):2030-1.
Clinical QuestionIs fixed-dose combination therapy (polypill) that combines antiplatelet, blood pressure-lowering, and cholesterol-lowering medications into a single pill associated with improved cardiovascular disease (CVD) risk factors or reduced all-cause mortality or fatal and nonfatal CVD events? Is the polypill associated with an increase in adverse events?Bottom LinePolypills are associated with greater reductions in systolic blood pressure and total cholesterol compared with usual care, placebo, or active comparators, but also with a 19% higher risk of any adverse event. Due to limited power from available evidence, the association of polypills with all-cause mortality or fatal and nonfatal CVD events is uncertain.
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