• Camille Rolland-Debord, Côme Bureau, Tymothee Poitou, Lisa Belin, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, and Alexandre Demoule.
• From the Intensive Care Unit and Respiratory Division (Département "R3S"), Groupe Hospitalier Pitié-Salpêtrière Charles Foix, AP-HP, 75013, Paris, France (C.R-D., C.B., T.P., T.S., A.D.) and Biostatistics, Public Health and Medical Information Department (L.B.), Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Paris, France; INSERM and UPMC, University Paris 6-Pierre et Marie Curie, UMR_S 1158, "Neurophysiologie Respiratoire Expérimentale et Clinique", Paris, France (C.R.-D., C.B., T.P., T.S., A.D.), Sorbonne Universités, University Paris 6-Pierre et Marie Curie, Paris, France (L.B.); Intensive Care Unit, CHU Limoges, 87042 Limoges Cedex, France (M.C.); Intensive Care Unit, Department of Anesthesiology, Critical Care and Perioperative Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France (S.P.); R2D2 EA-7281, Université d'Auvergne, Clermont-Ferrand, France (S.P.); CHU de Caen, Department of Intensive Care, Caen, France (N.T.); Medical ICU, Angers University Hospital, Angers, France (A.K.).
• Anesthesiology. 2017 Dec 1; 127 (6): 989-997.

BackgroundPatient-ventilator asynchrony is associated with a poorer outcome. The prevalence and severity of asynchrony during the early phase of weaning has never been specifically described. The authors' first aim was to evaluate the prognosis impact and the factors associated with asynchrony. Their second aim was to compare the prevalence of asynchrony according to two methods of detection: a visual inspection of signals and a computerized method integrating electromyographic activity of the diaphragm.MethodsThis was an ancillary study of a multicenter, randomized controlled trial comparing neurally adjusted ventilatory assist to pressure support ventilation. Asynchrony was quantified at 12, 24, 36, and 48 h after switching from controlled ventilation to a partial mode of ventilatory assistance according to the two methods. An asynchrony index greater than or equal to 10% defined severe asynchrony.ResultsA total of 103 patients ventilated for a median duration of 5 days (interquartile range, 3 to 9 days) were included. Whatever the method used for quantification, severe patient-ventilator asynchrony was not associated with an alteration of the outcome. No factor was associated with severe asynchrony. The prevalence of asynchrony was significantly lower when the quantification was based on flow and pressure than when it was based on the electromyographic activity of the diaphragm at 0.3 min (interquartile range, 0.2 to 0.8 min) and 4.7 min (interquartile range, 3.2 to 7.7 min; P < 0.0001), respectively.ConclusionsDuring the early phase of weaning in patients receiving a partial ventilatory mode, severe patient-ventilator asynchrony was not associated with adverse clinical outcome, although the prevalence of patient-ventilator asynchrony varies according to the definitions and methods used for detection.

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